Testosterone biases the amygdala toward social threat approach

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Testosterone biases the amygdala toward social threat approach

Testosterone enhances amygdala reactions to social threat, but it remains unclear whether this neuroendocrine mechanism is relevant for understanding its dominance-enhancing properties; namely, whether testosterone biases the human amygdala toward threat approach. This pharmacological functional magnetic-resonance imaging study shows that testosterone administration increases amygdala responses...

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Growing evidence indicates that normative pubertal maturation is associated with increased threat reactivity, and this developmental shift has been implicated in the increased rates of adolescent affective disorders. However, the neural mechanisms involved in this pubertal increase in threat reactivity remain unknown. Research in adults indicates that testosterone transiently decreases amygdala...

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Conditioned social dominance threat: observation of others' social dominance biases threat learning.

Social groups are organized along dominance hierarchies, which determine how we respond to threats posed by dominant and subordinate others. The persuasive impact of these dominance threats on mental and physical well-being has been well described but it is unknown how dominance rank of others bias our experience and learning in the first place. We introduce a model of conditioned social domina...

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Using fMRI, we measured brain activity while participants viewed photographs in which one person posed a potential threat to another. Visuospatial areas, specifically temporal-occipital junction, extrastriate, and fusiform cortices and right superior parietal lobe (BA7), responded when a threatening person was close to the personal space of another. Strikingly, this selectivity was absent when ...

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ژورنال

عنوان ژورنال: Science Advances

سال: 2015

ISSN: 2375-2548

DOI: 10.1126/sciadv.1400074